| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neuromedin-K receptor |
|---|
| Ligand | BDBM50337414 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_728369 (CHEMBL1685145) |
|---|
| Ki | 12±n/a nM |
|---|
| Citation |  Juhl, K; Hansen, T; Kehler, J; Khanzhin, NA; Nørgaard, MB; Ruhland, T; Larsen, DB; Jensen, KG; Steiniger-Brach, B; Nielsen, SM; Simonsen, KB Identification of a new series of non-peptidic NK3 receptor antagonists. Bioorg Med Chem Lett21:1498-501 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neuromedin-K receptor |
|---|
| Name: | Neuromedin-K receptor |
|---|
| Synonyms: | NK-3 receptor | NK-3R | NK3R | NK3R_HUMAN | NKR | Neurokinin 3 receptor | Neurokinin B receptor | Neurokinin-3 (NK-3) | Neuromedin-3 receptor (NK-3R) | Neuromedin-3 receptor (NK3) | Neuromedin-K receptor | Neuromedin-K receptor (NK-3 receptor) | Neuromedin-K receptor (NK3) | Neuromedin-K receptor(NK3R) | TAC3R | TACR3 | Tachykinin receptor 3 | Tachykinin receptor 3 (NK3) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 52221.96 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P29371 |
|---|
| Residue: | 465 |
|---|
| Sequence: | MATLPAAETWIDGGGGVGADAVNLTASLAAGAATGAVETGWLQLLDQAGNLSSSPSALGL
PVASPAPSQPWANLTNQFVQPSWRIALWSLAYGVVVAVAVLGNLIVIWIILAHKRMRTVT
NYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIA
VDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVQWPEG
PKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKM
MIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLN
KRFRAGFKRAFRWCPFIKVSSYDELELKTTRFHPNRQSSMYTVTRMESMTVVFDPNDADT
TRSSRKKRATPRDPSFNGCSRRNSKSASATSSFISSPYTSVDEYS
|
|
|
|---|
| BDBM50337414 |
|---|
| n/a |
|---|
| Name | BDBM50337414 |
|---|
| Synonyms: | (1S,2R)-1-(3,4-dichlorophenyl)-N-(4-fluorobenzyl)-N-methyl-2-((4-(2-(pyrrolidin-1-yl)acetyl)piperazin-1-yl)methyl)cyclopropanecarboxamide | CHEMBL1682679 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H35Cl2FN4O2 |
|---|
| Mol. Mass. | 561.518 |
|---|
| SMILES | CN(Cc1ccc(F)cc1)C(=O)[C@]1(C[C@H]1CN1CCN(CC1)C(=O)CN1CCCC1)c1ccc(Cl)c(Cl)c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
