Reaction Details |
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Target | Inosine-5'-monophosphate dehydrogenase 2 |
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Ligand | BDBM50338537 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_728666 (CHEMBL1685943) |
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Ki | 30±n/a nM |
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Citation | Felczak, K; Chen, L; Wilson, D; Williams, J; Vince, R; Petrelli, R; Jayaram, HN; Kusumanchi, P; Kumar, M; Pankiewicz, KW Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: targeting the pyrophosphate binding sub-domain. Bioorg Med Chem19:1594-605 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Inosine-5'-monophosphate dehydrogenase 2 |
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Name: | Inosine-5'-monophosphate dehydrogenase 2 |
Synonyms: | IMDH2_HUMAN | IMP dehydrogenase 2 | IMPD 2 | IMPD2 | IMPDH-II | IMPDH2 | Inosine 5'-monophosphate dehydrogenase II (IMPDH II) | Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) | Inosine-5 -monophosphate dehydrogenase 2 | Inosine-5'-monophosphate dehydrogenase (IMPDH) |
Type: | Enzyme |
Mol. Mass.: | 55806.87 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant IMPDH2 expressed in E. coli. |
Residue: | 514 |
Sequence: | MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT
LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVV
LSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMT
KREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDA
KKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVI
GGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVP
VIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM
DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR
AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
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BDBM50338537 |
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n/a |
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Name | BDBM50338537 |
Synonyms: | CHEMBL1683638 | Tiazofurin-5'-yl-2-ethyladenosin-5'-yl-difluromethylene bis(phosphonate) |
Type | Small organic molecule |
Emp. Form. | C22H29F2N7O13P2S |
Mol. Mass. | 731.514 |
SMILES | CCc1nc(N)c2ncn([C@H]3O[C@@H](COP(O)(=O)C(F)(F)P(O)(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)c4nc(cs4)C(N)=O)[C@H](O)[C@@H]3O)c2n1 |r| |
Structure |
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