| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-lactamase |
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| Ligand | BDBM50339145 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_733518 (CHEMBL1689856) |
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| IC50 | 128±n/a nM |
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| Citation |  Stachyra, T; Péchereau, MC; Bruneau, JM; Claudon, M; Frère, JM; Miossec, C; Coleman, K; Black, MT Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-beta-lactam beta-lactamase inhibitor. Antimicrob Agents Chemother54:5132-8 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-lactamase |
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| Name: | Beta-lactamase |
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| Synonyms: | AMPC_PSEAE | ampC | beta-Lactamase |
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| Type: | Enzyme |
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| Mol. Mass.: | 43406.87 |
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| Organism: | Pseudomonas aeruginosa (PAO1) |
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| Description: | P24735 |
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| Residue: | 397 |
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| Sequence: | MRDTRFPCLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISL
KGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWP
ALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNP
SIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVG
PGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEA
YDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRD
LGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR
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| BDBM50339145 |
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| n/a |
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| Name | BDBM50339145 |
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| Synonyms: | CHEMBL1689063 | trans-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octan-2-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C7H11N3O6S |
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| Mol. Mass. | 265.244 |
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| SMILES | NC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OS(O)(=O)=O |r| |
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| Structure | 
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