| Reaction Details |
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 | Report a problem with these data |
| Target | M1 family aminopeptidase |
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| Ligand | BDBM23971 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_735637 (CHEMBL1693339) |
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| Ki | 190±n/a nM |
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| Citation |  Velmourougane, G; Harbut, MB; Dalal, S; McGowan, S; Oellig, CA; Meinhardt, N; Whisstock, JC; Klemba, M; Greenbaum, DC Synthesis of new (-)-bestatin-based inhibitor libraries reveals a novel binding mode in the S1 pocket of the essential malaria M1 metalloaminopeptidase. J Med Chem54:1655-66 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| M1 family aminopeptidase |
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| Name: | M1 family aminopeptidase |
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| Synonyms: | AMPN_PLAF7 | M1AAP | Zinc aminopeptidase | m1-family aminopeptidase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 126072.31 |
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| Organism: | Plasmodium falciparum (isolate FcB1 / Columbia) |
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| Description: | ChEMBL_735637 |
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| Residue: | 1085 |
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| Sequence: | MKLTKGCAYKYIIFTVLILANILYDNKKRCMIKKNLRISSCGIISRLLKSNSNYNSFNKN
YNFTSAISELQFSNFWNLDILQKDIFSNIHNNKNKPQSYIIHKRLMSEKGDNNNNNHQNN
NGNDNKKRLGSVVNNEENTCSDKRMKPFEEGHGITQVDKMNNNSDHLQQNGVMNLNSNNV
ENNNNNNSVVVKKNEPKIHYRKDYKPSGFIINNVTLNINIHDNETIVRSVLDMDISKHNV
GEDLVFDGVGLKINEISINNKKLVEGEEYTYDNEFLTIFSKFVPKSKFAFSSEVIIHPET
NYALTGLYKSKNIIVSQCEATGFRRITFFIDRPDMMAKYDVTVTADKEKYPVLLSNGDKV
NEFEIPGGRHGARFNDPHLKPCYLFAVVAGDLKHLSATYITKYTKKKVELYVFSEEKYVS
KLQWALECLKKSMAFDEDYFGLEYDLSRLNLVAVSDFNVGAMENKGLNIFNANSLLASKK
NSIDFSYARILTVVGHEYFHNYTGNRVTLRDWFQLTLKEGLTVHRENLFSEEMTKTVTTR
LSHVDLLRSVQFLEDSSPLSHPIRPESYVSMENFYTTTVYDKGSEVMRMYLTILGEEYYK
KGFDIYIKKNDGNTATCEDFNYAMEQAYKMKKADNSANLNQYLLWFSQSGTPHVSFKYNY
DAEKKQYSIHVNQYTKPDENQKEKKPLFIPISVGLINPENGKEMISQTTLELTKESDTFV
FNNIAVKPIPSLFRGFSAPVYIEDNLTDEERILLLKYDSDAFVRYNSCTNIYMKQILMNY
NEFLKAKNEKLESFNLTPVNAQFIDAIKYLLEDPHADAGFKSYIVSLPQDRYIINFVSNL
DTDVLADTKEYIYKQIGDKLNDVYYKMFKSLEAKADDLTYFNDESHVDFDQMNMRTLRNT
LLSLLSKAQYPNILNEIIEHSKSPYPSNWLTSLSVSAYFDKYFELYDKTYKLSKDDELLL
QEWLKTVSRSDRKDIYEILKKLENEVLKDSKNPNDIRAVYLPFTNNLRRFHDISGKGYKL
IAEVITKTDKFNPMVATQLCEPFKLWNKLDTKRQELMLNEMNTMLQEPNISNNLKEYLLR
LTNKL
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| BDBM23971 |
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| n/a |
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| Name | BDBM23971 |
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| Synonyms: | (2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanoic acid | Bestatin | CHEMBL29292 | Ubenimex |
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| Type | Small organic molecule |
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| Emp. Form. | C16H24N2O4 |
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| Mol. Mass. | 308.3728 |
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| SMILES | CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O |
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| Structure | 
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