| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Adenosine receptor A2a |
|---|
| Ligand | BDBM50340042 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_739869 (CHEMBL1762929) |
|---|
| Ki | 8.9±n/a nM |
|---|
| Citation |  Harris, JM; Neustadt, BR; Zhang, H; Lachowicz, J; Cohen-Williams, M; Varty, G; Hao, J; Stamford, AW Potent and selective adenosine A(2A) receptor antagonists: [1,2,4]-triazolo[4,3-c]pyrimidin-3-ones. Bioorg Med Chem Lett21:2497-501 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Adenosine receptor A2a |
|---|
| Name: | Adenosine receptor A2a |
|---|
| Synonyms: | A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR) |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 44716.46 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P29274 |
|---|
| Residue: | 412 |
|---|
| Sequence: | MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI
PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR
AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF
NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG
LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR
KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG
YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
|
|
|
|---|
| BDBM50340042 |
|---|
| n/a |
|---|
| Name | BDBM50340042 |
|---|
| Synonyms: | 5-amino-2-benzyl-7-(2-(4-(methylsulfonyl)piperazin-1-yl)ethyl)-2H-pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidin-3(7H)-one | CHEMBL1762628 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H25N9O3S |
|---|
| Mol. Mass. | 471.536 |
|---|
| SMILES | CS(=O)(=O)N1CCN(CCn2ncc3c4nn(Cc5ccccc5)c(=O)n4c(N)nc23)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
