| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-8 |
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| Ligand | BDBM50273338 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_741342 (CHEMBL1764811) |
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| IC50 | >50000±n/a nM |
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| Citation |  Chu, W; Rothfuss, J; Zhou, D; Mach, RH Synthesis and evaluation of isatin analogs as caspase-3 inhibitors: introduction of a hydrophilic group increases potency in a whole cell assay. Bioorg Med Chem Lett21:2192-7 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Caspase-8 |
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| Name: | Caspase-8 |
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| Synonyms: | Apoptotic cysteine protease | Apoptotic protease Mch-5 | CAP4 | CASP-8 | CASP8 | CASP8_HUMAN | Caspase | Caspase-8 subunit p10 | Caspase-8 subunit p18 | FADD-homologous ICE/CED-3-like protease | FADD-like ICE | FLICE | ICE-like apoptotic protease 5 | MACH | MCH5 | MORT1-associated CED-3 homolog |
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| Type: | Enzyme |
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| Mol. Mass.: | 55373.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q14790 |
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| Residue: | 479 |
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| Sequence: | MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN
NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC
QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW
YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
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| BDBM50273338 |
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| n/a |
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| Name | BDBM50273338 |
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| Synonyms: | (S)-1-((1-(2-Fluoroethyl)-1H-[1,2,3]-triazol-4-yl)methyl)-5-(2(2,4-difluorophenoxymethyl)-pyrrolidine-1-sulfonyl)isatin | CHEMBL456799 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22F3N5O5S |
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| Mol. Mass. | 549.522 |
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| SMILES | FCCn1cc(CN2C(=O)C(=O)c3cc(ccc23)S(=O)(=O)N2CCC[C@H]2COc2ccc(F)cc2F)nn1 |r| |
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| Structure | 
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