Ki Summary

Reaction Details

Report a problem with these data

Target

Thymidylate synthase

Ligand

BDBM50340678

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_740134 (CHEMBL1763194)

IC50

0.6±n/a nM

Citation

Tzioumaki, N; Manta, S; Tsoukala, E; Vande Voorde, J; Liekens, S; Komiotis, D; Balzarini, J Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: novel 5-fluorouracil analogs that target thymidylate synthase. Eur J Med Chem46:993-1005 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Thymidylate synthase

Name:

Thymidylate synthase

Synonyms:

TS | TSase | TYSY_MOUSE | Tyms

Type:

PROTEIN

Mol. Mass.:

34957.15

Organism:

Mus musculus

Description:

ChEMBL_1340097

Residue:

307

Sequence:

MLVVGSELQSDAQQLSAEAPRHGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYS
LRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSAR
QEGDLGPVYGFQWRHFGAEYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKD
LPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPG
DFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLKILRKVETIDDFKVEDFQIEGYNPHPT
IKMEMAV

BDBM50340678

n/a

Name

BDBM50340678

Synonyms:

1-(beta-D-2-deoxy-erythro-pentofuranosyl)-5-fluorouracil | 2'-deoxy-5-fluorouridine | 5-Fluoro-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione | 5-Fluoro-1-(4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione | 5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione | 5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione | 5-fluoro-2'-Deoxy-uridine | 5-fluoro-2'-deoxyuridine | CHEMBL917 | FLOXURIDINE | FUDR | Fluoruridine Deoxyribose

Type

Small organic molecule

Emp. Form.

C9H11FN2O5

Mol. Mass.

246.1924

SMILES

OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O |r|

Structure