Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Nociceptin receptor | ||
| Ligand | BDBM50340708 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_740151 (CHEMBL1763211) | ||
| IC50 | 5.5±n/a nM | ||
| Citation |  Del Giudice, MR; Borioni, A; Bastanzio, G; Sbraccia, M; Mustazza, C; Sestili, I Synthesis and pharmacological evaluation of bivalent antagonists of the nociceptin opioid receptor. Eur J Med Chem46:1207-21 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Nociceptin receptor | |||
| Name: | Nociceptin receptor | ||
| Synonyms: | KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146 | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 40702.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P41146 | ||
| Residue: | 370 | ||
| Sequence: |
| ||
| BDBM50340708 | |||
| n/a | |||
| Name | BDBM50340708 | ||
| Synonyms: | 3-(9-(dimethylamino)nonyl)-8-(4-isopropylcyclohexyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | CHEMBL1762372 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C33H56N4O | ||
| Mol. Mass. | 524.8239 | ||
| SMILES | CC(C)[C@H]1CC[C@H](CC1)N1CCC2(CC1)N(CN(CCCCCCCCCN(C)C)C2=O)c1ccccc1 |r,wU:6.9,3.2,(13.12,-7.89,;13.88,-9.22,;13.1,-10.55,;15.42,-9.23,;16.2,-7.9,;17.74,-7.9,;18.5,-9.25,;17.72,-10.58,;16.18,-10.56,;20.04,-9.26,;20.8,-10.61,;22.33,-10.62,;23.12,-9.3,;22.36,-7.95,;20.81,-7.93,;23.88,-10.63,;25.38,-10.31,;25.55,-8.79,;26.88,-8.02,;28.21,-8.8,;29.55,-8.03,;30.88,-8.8,;32.22,-8.04,;33.55,-8.8,;34.89,-8.03,;36.22,-8.8,;37.55,-8.02,;38.89,-8.79,;38.89,-10.33,;40.22,-8.02,;24.15,-8.16,;23.83,-6.66,;23.26,-12.03,;21.72,-12.19,;21.09,-13.59,;21.99,-14.84,;23.53,-14.68,;24.16,-13.27,)| | ||
| Structure | 
| ||