| Reaction Details |
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 | Report a problem with these data |
| Target | Neuromedin-K receptor |
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| Ligand | BDBM50341076 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_739982 (CHEMBL1763042) |
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| Ki | 4000±n/a nM |
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| Citation |  Hoveyda, HR; Roy, MO; Blanc, S; Noël, S; Salvino, JM; Ator, MA; Fraser, G Discovery of 3-aryl-5-acylpiperazinyl-pyrazoles as antagonists to the NK3 receptor. Bioorg Med Chem Lett21:1991-6 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuromedin-K receptor |
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| Name: | Neuromedin-K receptor |
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| Synonyms: | NK3R_RAT | Neurokinin 3 receptor | Tac3r | Tacr3 |
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| Type: | n/a |
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| Mol. Mass.: | 51128.60 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_10983 |
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| Residue: | 452 |
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| Sequence: | MASVPRGENWTDGTVEVGTHTGNLSSALGVTEWLALQAGNFSSALGLPATTQAPSQVRAN
LTNQFVQPSWRIALWSLAYGLVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDAS
VAAFNTLINFIYGLHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKP
RLSATATKIVIGSIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGPKQHFTYHIIVII
LVYCFPLLIMGVTYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVVTFAICWL
PYHVYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRW
CPFIQVSSYDELELKTTRFHPTRQSSLYTVSRMESVTVLFDPNDGDPTKSSRKKRAVPRD
PSANGCSHRGSKSASTTSSFISSPYTSVDEYS
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| BDBM50341076 |
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| n/a |
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| Name | BDBM50341076 |
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| Synonyms: | (3-(4-chlorophenyl)-1H-pyrazol-5-yl)(4-(2-methoxybenzyl)piperazin-1-yl)methanone | CHEMBL1760339 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23ClN4O2 |
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| Mol. Mass. | 410.897 |
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| SMILES | COc1ccccc1CN1CCN(CC1)C(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1 |
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| Structure | 
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