| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent noradrenaline transporter |
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| Ligand | BDBM50322529 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_741840 (CHEMBL1769985) |
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| IC50 | 32±n/a nM |
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| Citation |  Carroll, FI; Muresan, AZ; Blough, BE; Navarro, HA; Mascarella, SW; Eaton, JB; Huang, X; Damaj, MI; Lukas, RJ Synthesis of 2-(substituted phenyl)-3,5,5-trimethylmorpholine analogues and their effects on monoamine uptake, nicotinic acetylcholine receptor function, and behavioral effects of nicotine. J Med Chem54:1441-8 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent noradrenaline transporter |
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| Name: | Sodium-dependent noradrenaline transporter |
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| Synonyms: | Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2 |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 69337.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P23975 |
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| Residue: | 617 |
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| Sequence: | MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
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| BDBM50322529 |
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| n/a |
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| Name | BDBM50322529 |
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| Synonyms: | (2S,3S)-2-(3-Fluorophenyl)-3,5,5-trimethylmorpholin-2-ol | CHEMBL1173275 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H18FNO2 |
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| Mol. Mass. | 239.2859 |
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| SMILES | C[C@@H]1NC(C)(C)CO[C@@]1(O)c1cccc(F)c1 |r| |
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| Structure | 
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