Reaction Details |
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Target | Cytochrome P450 3A4 |
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Ligand | BDBM50341712 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_743387 (CHEMBL1767686) |
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IC50 | >100000±n/a nM |
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Citation | Charrier, JD; Durrant, SJ; Golec, JM; Kay, DP; Knegtel, RM; MacCormick, S; Mortimore, M; O'Donnell, ME; Pinder, JL; Reaper, PM; Rutherford, AP; Wang, PS; Young, SC; Pollard, JR Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents. J Med Chem54:2320-30 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 3A4 |
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Name: | Cytochrome P450 3A4 |
Synonyms: | Albendazole monooxygenase | Albendazole sulfoxidase | CP3A4_HUMAN | CYP3A3 | CYP3A4 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 3A4 (CYP3A4) | Cytochrome P450 HLp | Nifedipine oxidase | Quinine 3-monooxygenase | Taurochenodeoxycholate 6-alpha-hydroxylase |
Type: | Enzyme |
Mol. Mass.: | 57349.57 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 503 |
Sequence: | MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF
DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI
AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS
MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV
FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI
IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV
NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS
KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG
GLLQPEKPVVLKVESRDGTVSGA
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BDBM50341712 |
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n/a |
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Name | BDBM50341712 |
Synonyms: | 3-amino-N,6-diphenylpyrazine-2-carboxamide | CHEMBL1766759 | US10479784, Compound I-15 | US10961232, Compound I-15 |
Type | Small organic molecule |
Emp. Form. | C17H14N4O |
Mol. Mass. | 290.3193 |
SMILES | Nc1ncc(nc1C(=O)Nc1ccccc1)-c1ccccc1 |
Structure |
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