| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 3 |
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| Ligand | BDBM50341853 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_743699 (CHEMBL1767468) |
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| IC50 | 18400±n/a nM |
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| Citation |  Botta, CB; Cabri, W; Cini, E; De Cesare, L; Fattorusso, C; Giannini, G; Persico, M; Petrella, A; Rondinelli, F; Rodriquez, M; Russo, A; Taddei, M Oxime amides as a novel zinc binding group in histone deacetylase inhibitors: synthesis, biological activity, and computational evaluation. J Med Chem54:2165-82 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 3 |
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| Name: | Histone deacetylase 3 |
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| Synonyms: | HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45 |
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| Type: | Enzyme |
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| Mol. Mass.: | 48829.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O15379 |
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| Residue: | 428 |
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| Sequence: | MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
DKESDVEI
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| BDBM50341853 |
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| n/a |
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| Name | BDBM50341853 |
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| Synonyms: | 2-(Hydroxyimino)-N1-methyl-N9-(3-(pyridine-3-yl)phenyl)nonanediamide | CHEMBL1767038 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H26N4O3 |
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| Mol. Mass. | 382.4561 |
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| SMILES | CNC(=O)C(CCCCCCC(=O)Nc1cccc(c1)-c1cccnc1)N=O |
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| Structure | 
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