Ki Summary

Reaction Details

Report a problem with these data

Target

6-phosphogluconate dehydrogenase, decarboxylating

Ligand

BDBM50148780

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_744988 (CHEMBL1772003)

35±n/a nM

Citation

Yep, A; Sorenson, RJ; Wilson, MR; Showalter, HD; Larsen, SD; Keller, PR; Woodard, RW Enediol mimics as inhibitors of the D-arabinose 5-phosphate isomerase (KdsD) from Francisella tularensis. Bioorg Med Chem Lett21:2679-82 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

6-phosphogluconate dehydrogenase, decarboxylating

Name:

6-phosphogluconate dehydrogenase, decarboxylating

Synonyms:

6-phosphogluconate dehydrogenase, decarboxylating, putative

Type:

PROTEIN

Mol. Mass.:

52169.87

Organism:

Trypanosoma brucei brucei (strain 927/4 GUTat10.1)

Description:

ChEMBL_744988

Residue:

479

Sequence:

MSMDVGVVGLGVMGANLALNIAEKGFKVAVFNRTYSKSEEFMKANASAPFAGNLKAFETM
EAFAASLKKPRKALILVQAGAATDSTIEQLKKVFEKGDILVDTGNAHFKDQGRRAQQLEA
AGLRFLGMGISGGEEGARKGPAFFPGGTLSVWEEIRPIVEAAAAKADDGRPCVTMNGSGG
AGSCVKMYHNSGEYAILQIWGEVFDILRAMGLNNDEVAAVLEDWKSKNFLKSYMLDISIA
AARAKDKDGSYLTEHVMDRIGSKGTGLWSAQEALEIGVPAPSLNMAVVSRQFTMYKTERQ
ANASNAPGITQSPGYTLKNKSPSGPEIKQLYDSVCIAIISCYAQMFQCLREMDKVHNFGL
NLPATIATFRAGCILQGYLLKPMTEAFEKNPNISNLMCAFQTEIRAGLQNYRDMVALITS
KLEVSIPVLSASLNYVTAMFTPTLKYGQLVSLQRDVFGRHGYERVDKDGRESFQWPELQ

BDBM50148780

n/a

Name

BDBM50148780

Synonyms:

((4R,5R)-5-(hydroxycarbamoyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl dihydrogen phosphate | (5-(hydroxycarbamoyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl dihydrogen phosphate | CHEMBL324609 | Phosphoric acid mono-((R)-(R)-5-hydroxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl) ester

Type

Small organic molecule

Emp. Form.

C7H14NO8P

Mol. Mass.

271.1617

SMILES

CC1(C)O[C@H](COP(O)(O)=O)[C@@H](O1)C(=O)NO

Structure