| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 2A |
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| Ligand | BDBM50342711 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_744161 (CHEMBL1771860) |
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| Ki | 810±n/a nM |
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| Citation |  Ortega, R; Hübner, H; Gmeiner, P; Masaguer, CF Aromatic ring functionalization of benzolactam derivatives: new potent dopamine D3 receptor ligands. Bioorg Med Chem Lett21:2670-4 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 2A |
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| Name: | 5-hydroxytryptamine receptor 2A |
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| Synonyms: | 5-HT-2 | 5-HT-2A | 5-HT2 | 5-HT2A | 5HT2A_PIG | HTR2A | Serotonin 2a (5-HT2a) receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 52679.13 |
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| Organism: | PIG |
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| Description: | 5-HT2 0 0::P50129 |
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| Residue: | 470 |
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| Sequence: | MDVLCEENTSLSSPTNSFMQLNDDTRLYHNDFNSGEANTSDAFNWTVDSENRTNLSCEGC
LSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHRRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGAL
LNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKS
SQLQTGQKENSKQDDKATENDCTMVALGKQHSEDAPADNSNTVNEKVSCV
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| BDBM50342711 |
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| n/a |
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| Name | BDBM50342711 |
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| Synonyms: | 7-methoxy-2-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-2,3,4,5-tetrahydro-1H-benzo[c]azepin-1-one | CHEMBL1771105 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H35N3O3 |
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| Mol. Mass. | 437.5744 |
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| SMILES | COc1ccc2c(CCCN(CCCCN3CCN(CC3)c3ccccc3OC)C2=O)c1 |
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| Structure | 
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