| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity protein kinase CLK2 |
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| Ligand | BDBM50342906 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_744228 (CHEMBL1772035) |
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| IC50 | 3331±n/a nM |
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| Citation |  Rosenthal, AS; Tanega, C; Shen, M; Mott, BT; Bougie, JM; Nguyen, DT; Misteli, T; Auld, DS; Maloney, DJ; Thomas, CJ Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk). Bioorg Med Chem Lett21:3152-8 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity protein kinase CLK2 |
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| Name: | Dual specificity protein kinase CLK2 |
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| Synonyms: | 2.7.12.1 | CDC-like kinase 2 | CDC-like kinase 2 (CLK2) | CDC2-like kinase 2 (CLK2) | CLK2 | CLK2_HUMAN |
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| Type: | n/a |
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| Mol. Mass.: | 60128.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49760 |
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| Residue: | 499 |
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| Sequence: | MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYD
DRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRR
RRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQC
VDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMC
ISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVN
SDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQ
PCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLD
WDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFA
RLRAEPPNKLWDSSRDISR
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| BDBM50342906 |
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| n/a |
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| Name | BDBM50342906 |
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| Synonyms: | CHEMBL1397614 | N-((1H-imidazol-2-yl)methyl)-6-(benzo[d][1,3]dioxol-5-yl)-N-methylquinazolin-4-amine |
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| Type | Small organic molecule |
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| Emp. Form. | C20H17N5O2 |
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| Mol. Mass. | 359.3813 |
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| SMILES | CN(Cc1ncc[nH]1)c1ncnc2ccc(cc12)-c1ccc2OCOc2c1 |
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| Structure | 
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