Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma
LigandBDBM50342910
Substrate/Competitorn/a
Meas. Tech.ChEMBL_744237 (CHEMBL1772044)
Kd 280±n/a nM
Citation Rosenthal, AS; Tanega, C; Shen, M; Mott, BT; Bougie, JM; Nguyen, DT; Misteli, T; Auld, DS; Maloney, DJ; Thomas, CJ Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk). Bioorg Med Chem Lett21:3152-8 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
Name:Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
Synonyms:PI(5)P 4-kinase type II gamma | PI42C_HUMAN | PIP4K2C | PIP4KII-gamma | PIP5K2C | Phosphatidylinositol-5-phosphate 4-kinase type II gamma | Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma
Type:PROTEIN
Mol. Mass.:47302.35
Organism:Homo sapiens (Human)
Description:ChEMBL_774614
Residue:421
Sequence:
MASSSVPPATVSAATAGPGPGFGFASKTKKKHFVQQKVKVFRAADPLVGVFLWGVAHSIN
ELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQ
DYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNT
LLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTL
KDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEA
PVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAE
GAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGAEISTVHPEQYAKRFLDFITNIF
A
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50342910
n/a
NameBDBM50342910
Synonyms:6-(benzo[d][1,3]dioxol-5-yl)-N-((2-methylthiazol-4-yl)methyl)quinazolin-4-amine | CHEMBL1435542
TypeSmall organic molecule
Emp. Form.C20H16N4O2S
Mol. Mass.376.432
SMILESCc1nc(CNc2ncnc3ccc(cc23)-c2ccc3OCOc3c2)cs1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: