| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylinositol 4-kinase beta |
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| Ligand | BDBM50342892 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_744241 (CHEMBL1772048) |
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| Kd | 430±n/a nM |
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| Citation |  Rosenthal, AS; Tanega, C; Shen, M; Mott, BT; Bougie, JM; Nguyen, DT; Misteli, T; Auld, DS; Maloney, DJ; Thomas, CJ Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk). Bioorg Med Chem Lett21:3152-8 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylinositol 4-kinase beta |
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| Name: | Phosphatidylinositol 4-kinase beta |
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| Synonyms: | NPIK | PI4-kinase beta subunit | PI4K-beta | PI4K92 | PI4KB | PI4KB_HUMAN | PI4Kbeta | PIK4B | PIK4CB | Phosphatidylinositol 4-kinase beta | Phosphatidylinositol 4-kinase, PI4K | PtdIns 4-kinase beta |
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| Type: | Protein |
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| Mol. Mass.: | 91373.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 816 |
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| Sequence: | MGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVK
LLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGAAVASGTAKGARRRR
QNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLL
NMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLI
LSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVEN
EDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLN
HKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPE
NRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCD
NISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEK
VRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKI
LVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGY
CLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGG
LDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSM
TEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
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| BDBM50342892 |
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| n/a |
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| Name | BDBM50342892 |
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| Synonyms: | 6-(benzo[d][1,3]dioxol-5-yl)-N-((tetrahydrofuran-3-yl)methyl)quinazolin-4-amine | CHEMBL1436585 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19N3O3 |
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| Mol. Mass. | 349.3832 |
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| SMILES | C(Nc1ncnc2ccc(cc12)-c1ccc2OCOc2c1)C1CCOC1 |
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| Structure | 
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