| Reaction Details |
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 | Report a problem with these data |
| Target | DNA polymerase I, thermostable |
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| Ligand | BDBM50343037 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_744786 (CHEMBL1772807) |
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| IC50 | 8000±n/a nM |
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| Citation |  Liu, XH; Ruan, BF; Liu, JX; Song, BA; Jing, LH; Li, J; Yang, Y; Zhu, HL; Qi, XB Design and synthesis of N-phenylacetyl (sulfonyl) 4,5-dihydropyrazole derivatives as potential antitumor agents. Bioorg Med Chem Lett21:2916-20 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA polymerase I, thermostable |
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| Name: | DNA polymerase I, thermostable |
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| Synonyms: | DNA polymerase I, thermostable | DPO1_THEAQ | Taq polymerase 1 | pol1 | polA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 93906.95 |
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| Organism: | Thermus aquaticus |
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| Description: | ChEMBL_1289218 |
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| Residue: | 832 |
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| Sequence: | MRGMLPLFEPKGRVLLVDGHHLAYRTFHALKGLTTSRGEPVQAVYGFAKSLLKALKEDGD
AVIVVFDAKAPSFRHEAYGGYKAGRAPTPEDFPRQLALIKELVDLLGLARLEVPGYEADD
VLASLAKKAEKEGYEVRILTADKDLYQLLSDRIHVLHPEGYLITPAWLWEKYGLRPDQWA
DYRALTGDESDNLPGVKGIGEKTARKLLEEWGSLEALLKNLDRLKPAIREKILAHMDDLK
LSWDLAKVRTDLPLEVDFAKRREPDRERLRAFLERLEFGSLLHEFGLLESPKALEEAPWP
PPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALRDLKEARGLLAKDLSVLA
LREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRYGGEWTEEAGERAALSERLFANLWGRL
EGEERLLWLYREVERPLSAVLAHMEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGH
PFNLNSRDQLERVLFDELGLPAIGKTEKTGKRSTSAAVLEALREAHPIVEKILQYRELTK
LKSTYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQRIRRAFIA
EEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTETASWMFGVPREAVDPLMRR
AAKTINFGVLYGMSAHRLSQELAIPYEEAQAFIERYFQSFPKVRAWIEKTLEEGRRRGYV
ETLFGRRRYVPDLEARVKSVREAAERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARML
LQVHDELVLEAPKERAEAVARLAKEVMEGVYPLAVPLEVEVGIGEDWLSAKE
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| BDBM50343037 |
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| n/a |
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| Name | BDBM50343037 |
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| Synonyms: | (5-(2-Hydroxyphenyl)-3-methyl-4,5-dihydropyrazol-1-yl)(phenyl)methanone | CHEMBL1770486 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16N2O2 |
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| Mol. Mass. | 280.3211 |
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| SMILES | CC1=NN(C(C1)c1ccccc1O)C(=O)c1ccccc1 |t:1| |
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| Structure | 
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