| Reaction Details |
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 | Report a problem with these data |
| Target | Collagenase |
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| Ligand | BDBM50343083 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_744955 |
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| Ki | 0.600000±n/a nM |
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| Citation |  Barta TE; Becker DP; Bedell LJ; Easton AM; Hockerman SL; Kiefer J; Munie GE; Mathis KJ; Li MH; Rico JG; Villamil CI; Williams JM MMP-13 selectivea-sulfone hydroxamates: a survey of P1' heterocyclic amide isosteres. Bioorg Med Chem Lett 21:2820-2 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Collagenase |
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| Name: | Matrix metalloproteinase (1 and 13) |
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| Synonyms: | Collagenase 3 | MMP-13 | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13) |
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| Type: | Enzyme |
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| Mol. Mass.: | 53808.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 471 |
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| Sequence: | MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENA
ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY
RIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDG
PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM
FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGET
MIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGY
DILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI
EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
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| BDBM50343083 |
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| n/a |
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| Name | BDBM50343083 |
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| Synonyms: | CHEMBL1771218 | N-hydroxy-4-(4-(3-(5-(5-methylpyridin-2-yl)-1H-tetrazol-1-yl)propoxy)phenylsulfonyl)tetrahydro-2H-pyran-4-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C22H26N6O6S |
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| Mol. Mass. | 502.543 |
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| SMILES | Cc1ccc(nc1)-c1nnnn1CCCOc1ccc(cc1)S(=O)(=O)C1(CCOCC1)C(=O)NO |
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| Structure | 
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