| Reaction Details |
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 | Report a problem with these data |
| Target | Polyphenol oxidase 2 |
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| Ligand | BDBM50344056 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_748535 (CHEMBL1780388) |
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| IC50 | >5000000±n/a nM |
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| Citation |  Matos, MJ; Santana, L; Uriarte, E; Delogu, G; Corda, M; Fadda, MB; Era, B; Fais, A New halogenated phenylcoumarins as tyrosinase inhibitors. Bioorg Med Chem Lett21:3342-5 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyphenol oxidase 2 |
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| Name: | Polyphenol oxidase 2 |
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| Synonyms: | Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase |
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| Type: | Protein |
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| Mol. Mass.: | 63923.66 |
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| Organism: | Agaricus bisporus (Common mushroom) |
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| Description: | O42713 |
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| Residue: | 556 |
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| Sequence: | MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLP
FTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWV
QAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPY
GDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDD
QHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVW
VTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGG
TKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKK
FELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNH
YLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDH
TQARVVFDDVAVHVIN
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| BDBM50344056 |
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| n/a |
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| Name | BDBM50344056 |
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| Synonyms: | 6-Bromo-8-methoxy-3-phenylcoumarin | CHEMBL1777814 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H11BrO3 |
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| Mol. Mass. | 331.161 |
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| SMILES | COc1cc(Br)cc2cc(-c3ccccc3)c(=O)oc12 |
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| Structure | 
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