| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Polyphenol oxidase 2 |
|---|
| Ligand | BDBM50344062 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_748536 (CHEMBL1780389) |
|---|
| Ki | 189000±n/a nM |
|---|
| Citation |  Matos, MJ; Santana, L; Uriarte, E; Delogu, G; Corda, M; Fadda, MB; Era, B; Fais, A New halogenated phenylcoumarins as tyrosinase inhibitors. Bioorg Med Chem Lett21:3342-5 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Polyphenol oxidase 2 |
|---|
| Name: | Polyphenol oxidase 2 |
|---|
| Synonyms: | Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 63923.66 |
|---|
| Organism: | Agaricus bisporus (Common mushroom) |
|---|
| Description: | O42713 |
|---|
| Residue: | 556 |
|---|
| Sequence: | MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLP
FTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWV
QAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPY
GDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDD
QHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVW
VTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGG
TKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKK
FELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNH
YLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDH
TQARVVFDDVAVHVIN
|
|
|
|---|
| BDBM50344062 |
|---|
| n/a |
|---|
| Name | BDBM50344062 |
|---|
| Synonyms: | 6-Bromo-8-hydroxy-3-(4'-hydroxyphenyl)coumarin | CHEMBL1777849 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H9BrO4 |
|---|
| Mol. Mass. | 333.134 |
|---|
| SMILES | Oc1ccc(cc1)-c1cc2cc(Br)cc(O)c2oc1=O |
|---|
| Structure | 
|
|---|
Search and Browse
