| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosinase |
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| Ligand | BDBM50174558 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_748537 (CHEMBL1780390) |
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| IC50 | 420000±n/a nM |
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| Citation |  Matos, MJ; Santana, L; Uriarte, E; Delogu, G; Corda, M; Fadda, MB; Era, B; Fais, A New halogenated phenylcoumarins as tyrosinase inhibitors. Bioorg Med Chem Lett21:3342-5 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosinase |
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| Name: | Tyrosinase |
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| Synonyms: | LB24-AB | Monophenol monooxygenase | SK29-AB | TYR | TYRO_HUMAN | Tumor rejection antigen AB |
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| Type: | Protein |
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| Mol. Mass.: | 60388.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14679 |
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| Residue: | 529 |
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| Sequence: | MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILL
SNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVR
RNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMH
YYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRWEQEIQKLTGDENFTIPYWDWRD
AEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLEEYNSHQSLCNGTPEGPLRRN
PGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFASPLTGIADASQS
SMHNALHIYMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLQEVYPEANAPIGH
NRESYMVPFIPLYRNGDFFISSKDLGYDYSYLQDSDPDSFQDYIKSYLEQASRIWSWLLG
AAMVGAVLTALLAGLVSLLCRHKRKQLPEEKQPLLMEKEDYHSLYQSHL
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| BDBM50174558 |
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| n/a |
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| Name | BDBM50174558 |
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| Synonyms: | 7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chromen-2-one | CHEMBL51628 | Coumarin derivative, 3a | beta-umbelliferone | hydrangin | skimmetin | umbelliferone |
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| Type | Small organic molecule |
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| Emp. Form. | C9H6O3 |
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| Mol. Mass. | 162.1421 |
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| SMILES | Oc1ccc2ccc(=O)oc2c1 |
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| Structure | 
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