Ki Summary

Reaction Details

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Target

Sigma non-opioid intracellular receptor 1

Ligand

BDBM50344433

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_748646 (CHEMBL1780499)

>1000±n/a nM

Citation

Rack, E; Fröhlich, R; Schepmann, D; Wünsch, B Design, synthesis and pharmacological evaluation of spirocyclics(1) receptor ligands with exocyclic amino moiety (increased distance 1). Bioorg Med Chem19:3141-51 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Sigma non-opioid intracellular receptor 1

Name:

Sigma non-opioid intracellular receptor 1

Synonyms:

Type:

Protein

Mol. Mass.:

25307.17

Organism:

Cavia porcellus (Guinea pig)

Description:

Q60492

Residue:

223

Sequence:

MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSK
LIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP

BDBM50344433

n/a

Name

BDBM50344433

Synonyms:

CHEMBL1779997 | trans-3-Methoxy-N,N-dimethyl-3,4-dihydrospiro-[[2]benzopyran-1,1'-cyclohexan]-4'-amine

Type

Small organic molecule

Emp. Form.

C17H25NO2

Mol. Mass.

275.3859

SMILES

COC1Cc2ccccc2[C@@]2(CC[C@@H](CC2)N(C)C)O1 |r,wU:10.20,wD:13.17,(24.05,-6.81,;22.71,-7.59,;22.7,-9.14,;24.04,-9.91,;24.03,-11.45,;25.35,-12.22,;25.35,-13.75,;24.02,-14.52,;22.7,-13.75,;22.7,-12.22,;21.36,-11.45,;20.59,-12.8,;18.87,-12.18,;17.67,-12.6,;18.44,-11.24,;20.09,-11.87,;17.66,-14.15,;16.32,-14.92,;19,-14.93,;21.36,-9.9,)|

Structure