| Reaction Details |
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 | Report a problem with these data |
| Target | Plasmepsin II |
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| Ligand | BDBM50344445 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_747699 (CHEMBL1780854) |
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| IC50 | 11500±n/a nM |
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| Citation |  McKay, PB; Peters, MB; Carta, G; Flood, CT; Dempsey, E; Bell, A; Berry, C; Lloyd, DG; Fayne, D Identification of plasmepsin inhibitors as selective anti-malarial agents using ligand based drug design. Bioorg Med Chem Lett21:3335-41 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Plasmepsin II |
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| Name: | Plasmepsin II |
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| Synonyms: | Aspartic hemoglobinase II | PFAPD | PLM2_PLAFX | PMII | Plasmepsin 2 | Plasmepsin 2 (PM-II) | Plasmepsin-II |
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| Type: | Enzyme |
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| Mol. Mass.: | 51482.09 |
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| Organism: | Plasmodium falciparum |
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| Description: | P46925 |
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| Residue: | 453 |
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| Sequence: | MDITVREHDFKHGFIKSNSTFDGLNIDNSKNKKKIQKGFQILYVLLFCSVMCGLFYYVYE
NVWLQRDNEMNEILKNSEHLTIGFKVENAHDRILKTIKTHKLKNYIKESVNFLNSGLTKT
NYLGSSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKH
LYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYT
ASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEER
FYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDV
IKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPV
PTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL
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| BDBM50344445 |
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| n/a |
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| Name | BDBM50344445 |
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| Synonyms: | CHEMBL1780014 | N-(3-(1-(2-(2-(3-butoxyphenyl)quinoline-4-carbonyl)hydrazono)ethyl)phenyl)pivalamide |
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| Type | Small organic molecule |
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| Emp. Form. | C33H36N4O3 |
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| Mol. Mass. | 536.6639 |
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| SMILES | CCCCOc1cccc(c1)-c1cc(C(=O)NN=C(C)c2cccc(NC(=O)C(C)(C)C)c2)c2ccccc2n1 |w:17.17| |
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| Structure | 
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