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TargetProgrammed cell death protein 4
LigandBDBM36609
Substrate/Competitorn/a
Meas. Tech.ChEMBL_751484 (CHEMBL1787264)
EC50 50±n/a nM
Citation Grkovic, T; Blees, JS; Colburn, NH; Schmid, T; Thomas, CL; Henrich, CJ; McMahon, JB; Gustafson, KR Cryptocaryols A-H,a-pyrone-containing 1,3-polyols from Cryptocarya sp. implicated in stabilizing the tumor suppressor Pdcd4. J Nat Prod74:1015-20 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Programmed cell death protein 4
Name:Programmed cell death protein 4
Synonyms:H731 | Neoplastic transformation inhibitor protein | Nuclear antigen H731-like | PDCD4 | PDCD4_HUMAN | Protein 197/15a
Type:PROTEIN
Mol. Mass.:51720.55
Organism:Homo sapiens (Human)
Description:ChEMBL_776474
Residue:469
Sequence:
MDVENEQILNVNPADPDNLSDSLFSGDEENAGTEEIKNEINGNWISASSINEARINAKAK
RRLRKNSSRDSGRGDSVSDSGSDALRSGLTVPTSPKGRLLDRRSRSGKGRGLPKKGGAGG
KGVWGTPGQVYDVEEVDVKDPNYDDDQENCVYETVVLPLDERAFEKTLTPIIQEYFEHGD
TNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEKSF
DKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATV
LLSMSKGGKRKDSVWGSGGGQQSVNHLVKEIDMLLKEYLLSGDISEAEHCLKELEVPHFH
HELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDVP
HSYSVLERFVEECFQAGIISKQLRDLCPSRGRKRFVSEGDGGRLKPESY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM36609
n/a
NameBDBM36609
Synonyms:Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, Compound Ramycin
TypeSmall organic molecule
Emp. Form.C51H79NO13
Mol. Mass.914.1719
SMILESCO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@H]3C(=O)O2)OC)CC[C@H]1O |c:14,33,t:29,31|
Structure
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