| Reaction Details |
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 | Report a problem with these data |
| Target | Melatonin receptor type 1B |
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| Ligand | BDBM50347592 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_755972 (CHEMBL1803862) |
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| Ki | 0.33±n/a nM |
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| Citation |  Koike, T; Takai, T; Hoashi, Y; Nakayama, M; Kosugi, Y; Nakashima, M; Yoshikubo, S; Hirai, K; Uchikawa, O Synthesis of a novel series of tricyclic dihydrofuran derivatives: discovery of 8,9-dihydrofuro[3,2-c]pyrazolo[1,5-a]pyridines as melatonin receptor (MT1/MT2) ligands. J Med Chem54:4207-18 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melatonin receptor type 1B |
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| Name: | Melatonin receptor type 1B |
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| Synonyms: | MTNR1B | MTR1B_HUMAN | Mel-1B-R | Mel1b melatonin receptor | Melatonin 1B | Melatonin receptor | Melatonin receptor type 1B | Melatonin receptor type 2 (MT2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 40203.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49286 |
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| Residue: | 362 |
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| Sequence: | MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLL
VILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVM
GLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGS
LEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRL
CLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFN
SCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQAD
AL
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| BDBM50347592 |
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| n/a |
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| Name | BDBM50347592 |
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| Synonyms: | CHEMBL1802030 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H16F3N3O2 |
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| Mol. Mass. | 327.3016 |
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| SMILES | CCC(=O)NCCc1c(nn2ccc3OCCc3c12)C(F)(F)F |
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| Structure | 
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