| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity protein kinase CLK1 |
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| Ligand | BDBM50312212 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_756288 (CHEMBL1805101) |
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| IC50 | 190±n/a nM |
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| Citation |  Debdab, M; Carreaux, F; Renault, S; Soundararajan, M; Fedorov, O; Filippakopoulos, P; Lozach, O; Babault, L; Tahtouh, T; Baratte, B; Ogawa, Y; Hagiwara, M; Eisenreich, A; Rauch, U; Knapp, S; Meijer, L; Bazureau, JP Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing. J Med Chem54:4172-86 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity protein kinase CLK1 |
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| Name: | Dual specificity protein kinase CLK1 |
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| Synonyms: | CDC-like kinase 1 | CLK1_MOUSE | Clk | Clk1 | Protein kinase STY | Sty |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57124.52 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1502245 |
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| Residue: | 483 |
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| Sequence: | MRHSKRTYCPDWDERDWDYGTWRSSSSHKRKKRSHSSAREQKRCRYDHSKTTDSYYLESR
SINEKAYHSRRYVDEYRNDYMGYEPGHPYGEPGSRYQMHSSKSSGRSGRSSYKSKHRSRH
HTSQHHSHGKSHRRKRSRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDH
KVGGRRVAVKIVKNVDRYCEAAQSEIQVLEHLNTTDPHSTFRCVQMLEWFEHRGHICIVF
ELLGLSTYDFIKENSFLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVKSDY
TEAYNPKMKRDERTIVNPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCD
VWSIGCILIEYYLGFTVFPTHDSREHLAMMERILGPLPKHMIQKTRKRRYFHHDRLDWDE
HSSAGRYVSRRCKPLKEFMLSQDAEHELLFDLIGKMLEYDPAKRITLKEALKHPFFYPLK
KHT
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| BDBM50312212 |
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| n/a |
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| Name | BDBM50312212 |
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| Synonyms: | (5Z)-5-[(1,3-benzodioxo-5-yl)methylene]-3-methyl-2-[(2-aminoethyl)amino]-3,5-dihydro-4H-imidazol-4-onehydrochloride | CHEMBL1081243 | CHEMBL1179821 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H16N4O3 |
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| Mol. Mass. | 288.3018 |
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| SMILES | CN1C(=O)C(=Cc2ccc3OCOc3c2)N=C1NCCN |w:5.5,c:17| |
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| Structure | 
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