Reaction Details |
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Target | Protein-S-isoprenylcysteine O-methyltransferase |
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Ligand | BDBM50348033 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_757250 (CHEMBL1803626) |
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IC50 | 90±n/a nM |
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Citation | Judd, WR; Slattum, PM; Hoang, KC; Bhoite, L; Valppu, L; Alberts, G; Brown, B; Roth, B; Ostanin, K; Huang, L; Wettstein, D; Richards, B; Willardsen, JA Discovery and SAR of methylated tetrahydropyranyl derivatives as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT). J Med Chem54:5031-47 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Protein-S-isoprenylcysteine O-methyltransferase |
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Name: | Protein-S-isoprenylcysteine O-methyltransferase |
Synonyms: | ICMT | ICMT_HUMAN | Isoprenylcysteine carboxyl methyltransferase | PCCMT |
Type: | PROTEIN |
Mol. Mass.: | 31943.26 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_956034 |
Residue: | 284 |
Sequence: | MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYR
PPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLS
LDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFT
AGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTV
WRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
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BDBM50348033 |
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n/a |
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Name | BDBM50348033 |
Synonyms: | CHEMBL1800479 |
Type | Small organic molecule |
Emp. Form. | C22H26F3NO2 |
Mol. Mass. | 393.4425 |
SMILES | CC1(C)CC(CCNc2cccc(OC(F)(F)F)c2)(CCO1)c1ccccc1 |
Structure |
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