| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Collagenase 3 |
|---|
| Ligand | BDBM11870 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_754464 (CHEMBL1806089) |
|---|
| IC50 | 0.150000±n/a nM |
|---|
| Citation |  Becker, DP; Barta, TE; Bedell, LJ; Boehm, TL; Bond, BR; Carroll, J; Carron, CP; Decrescenzo, GA; Easton, AM; Freskos, JN; Funckes-Shippy, CL; Heron, M; Hockerman, S; Howard, CP; Kiefer, JR; Li, MH; Mathis, KJ; McDonald, JJ; Mehta, PP; Munie, GE; Sunyer, T; Swearingen, CA; Villamil, CI; Welsch, D; Williams, JM; Yu, Y; Yao, J Orally active MMP-1 sparinga-tetrahydropyranyl anda-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease. J Med Chem53:6653-80 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Collagenase 3 |
|---|
| Name: | Collagenase 3 |
|---|
| Synonyms: | MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 53808.06 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P45452 |
|---|
| Residue: | 471 |
|---|
| Sequence: | MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENA
ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY
RIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDG
PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM
FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGET
MIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGY
DILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI
EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
|
|
|
|---|
| BDBM11870 |
|---|
| n/a |
|---|
| Name | BDBM11870 |
|---|
| Synonyms: | 4-{[4-(4-Chlorophenoxy)phenyl]sulfonyl}-N-hydroxy tetrahydro-2H-pyran-4-carboxamide | 4-{[4-(4-chlorophenoxy)benzene]sulfonyl}-N-hydroxyoxane-4-carboxamide | alpha-sulfone 21 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H18ClNO6S |
|---|
| Mol. Mass. | 411.857 |
|---|
| SMILES | ONC(=O)C1(CCOCC1)S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
