Reaction Details |
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Target | D(4) dopamine receptor |
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Ligand | BDBM50349866 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_760691 (CHEMBL1815676) |
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Ki | 212±n/a nM |
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Citation | Vangveravong, S; Zhang, Z; Taylor, M; Bearden, M; Xu, J; Cui, J; Wang, W; Luedtke, RR; Mach, RH Synthesis and characterization of selective dopamine D2 receptor ligands using aripiprazole as the lead compound. Bioorg Med Chem19:3502-11 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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D(4) dopamine receptor |
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Name: | D(4) dopamine receptor |
Synonyms: | D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor |
Type: | Enzyme |
Mol. Mass.: | 48373.19 |
Organism: | Homo sapiens (Human) |
Description: | P21917 |
Residue: | 419 |
Sequence: | MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVA
TERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCT
ASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGR
DPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSG
PGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPG
LPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWT
PFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
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BDBM50349866 |
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n/a |
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Name | BDBM50349866 |
Synonyms: | CHEMBL160296 | CHEMBL1813590 | UNC10108016 | US9156822, 39 |
Type | Small organic molecule |
Emp. Form. | C24H31N3O3 |
Mol. Mass. | 409.5212 |
SMILES | COc1ccccc1N1CCN(CCCCOc2ccc3CCC(=O)Nc3c2)CC1 |
Structure |
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