| Reaction Details |
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 | Report a problem with these data |
| Target | Poly(ADP-ribose) glycohydrolase |
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| Ligand | BDBM50350102 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_760969 (CHEMBL1814966) |
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| IC50 | 21000±n/a nM |
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| Citation |  Steffen, JD; Coyle, DL; Damodaran, K; Beroza, P; Jacobson, MK Discovery and structure-activity relationships of modified salicylanilides as cell permeable inhibitors of poly(ADP-ribose) glycohydrolase (PARG). J Med Chem54:5403-13 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Poly(ADP-ribose) glycohydrolase |
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| Name: | Poly(ADP-ribose) glycohydrolase |
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| Synonyms: | PARG | PARG_HUMAN | Poly(ADP-ribose) glycohydrolase | poly(ADP-ribose) glycohydrolase (PARG) |
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| Type: | Protein |
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| Mol. Mass.: | 111107.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q86W56 |
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| Residue: | 976 |
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| Sequence: | MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPG
RAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQ
HNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPE
QFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKS
CDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEP
ESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTK
GGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKA
EDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANH
TVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQ
TALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKI
ALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDIN
FNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHV
TYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNEC
LIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEK
MRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYF
TFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAV
ESCAETADHSGQRTGT
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| BDBM50350102 |
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| n/a |
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| Name | BDBM50350102 |
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| Synonyms: | CHEMBL1813893 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H14Cl2F3NO3 |
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| Mol. Mass. | 492.274 |
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| SMILES | Oc1c(Cl)cc(Cl)cc1C(=O)Nc1ccc(Oc2ccc3ccccc3c2)c(c1)C(F)(F)F |
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| Structure | 
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