| Reaction Details |
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 | Report a problem with these data |
| Target | Glycogen phosphorylase, liver form |
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| Ligand | BDBM50136414 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_762685 (CHEMBL1817503) |
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| IC50 | 120±n/a nM |
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| Citation |  Habash, M; Taha, MO Ligand-based modelling followed by synthetic exploration unveil novel glycogen phosphorylase inhibitory leads. Bioorg Med Chem19:4746-71 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycogen phosphorylase, liver form |
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| Name: | Glycogen phosphorylase, liver form |
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| Synonyms: | Glycogen Phosphorylase (PYGL) | Glycogen Phosphorylase, liver form | Liver glycogen phosphorylase | PYGL | PYGL_HUMAN |
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| Type: | Homodimer |
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| Mol. Mass.: | 97153.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Dimers associate into a tetramer to form the enzymatically active phosphorylase A. |
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| Residue: | 847 |
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| Sequence: | MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTV
RDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDI
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEA
DDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVN
TMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKL
PWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFP
KDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKF
QNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQ
ENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFV
PRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPA
TDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVA
ALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEA
YVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNE
SNKVNGN
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| BDBM50136414 |
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| n/a |
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| Name | BDBM50136414 |
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| Synonyms: | 5-Fluoro-1H-indole-2-carboxylic acid (1-methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl)-amide | CHEMBL136573 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H16FN3O2 |
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| Mol. Mass. | 337.3476 |
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| SMILES | CN1C(=O)C(Cc2ccccc12)NC(=O)c1cc2cc(F)ccc2[nH]1 |
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| Structure | 
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