Reaction Details |
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Target | Thymidylate synthase ThyA |
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Ligand | BDBM50351762 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_764952 (CHEMBL1827109) |
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IC50 | >50000±n/a nM |
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Citation | Kögler, M; Vanderhoydonck, B; De Jonghe, S; Rozenski, J; Van Belle, K; Herman, J; Louat, T; Parchina, A; Sibley, C; Lescrinier, E; Herdewijn, P Synthesis and evaluation of 5-substituted 2'-deoxyuridine monophosphate analogues as inhibitors of flavin-dependent thymidylate synthase in Mycobacterium tuberculosis. J Med Chem54:4847-62 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Thymidylate synthase ThyA |
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Name: | Thymidylate synthase ThyA |
Synonyms: | TS | TSase | TYSY_MYCTU | Thymidylate synthase | thyA |
Type: | PROTEIN |
Mol. Mass.: | 29848.00 |
Organism: | Mycobacterium tuberculosis |
Description: | ChEMBL_764952 |
Residue: | 263 |
Sequence: | MTPYEDLLRFVLETGTPKSDRTGTGTRSLFGQQMRYDLSAGFPLLTTKKVHFKSVAYELL
WFLRGDSNIGWLHEHGVTIWDEWASDTGELGPIYGVQWRSWPAPSGEHIDQISAALDLLR
TDPDSRRIIVSAWNVGEIERMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIAS
YALLTHMMAAQAGLSVGEFIWTGGDCHIYDNHVEQVRLQLSREPRPYPKLLLADRDSIFE
YTYEDIVVKNYDPHPAIKAPVAV
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BDBM50351762 |
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n/a |
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Name | BDBM50351762 |
Synonyms: | CHEMBL1823494 |
Type | Small organic molecule |
Emp. Form. | C15H14FN2O8P |
Mol. Mass. | 400.2535 |
SMILES | O[C@H]1C[C@@H](O[C@@H]1COP([O-])([O-])=O)n1cc(-c2ccc(F)cc2)c(=O)[nH]c1=O |r| |
Structure |
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