| Reaction Details |
|---|
 | Report a problem with these data |
| Target | M-phase inducer phosphatase 2 |
|---|
| Ligand | BDBM50351774 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_765399 (CHEMBL1828247) |
|---|
| IC50 | 14030±n/a nM |
|---|
| Citation |  Sun, LP; Shen, Q; Piao, HH; Ma, WP; Gao, LX; Zhang, W; Nan, FJ; Li, J; Piao, HR Synthesis and biological evaluation of (±)-3-(2-(2-fluorobenzyloxy) naphthalen-6-yl)-2-aminopropanoic acid derivatives as novel PTP1B inhibitors. Eur J Med Chem46:3630-8 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| M-phase inducer phosphatase 2 |
|---|
| Name: | M-phase inducer phosphatase 2 |
|---|
| Synonyms: | CDC25B | CDC25HU2 | Dual specificity phosphatase (CDC25B) | Dual specificity phosphatase Cdc25B | M-phase inducer phosphatase 2 (CDC25B) | MPIP2_HUMAN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 64985.27 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 580 |
|---|
| Sequence: | MEVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPVRAAASSPVTTLTQTMH
DLAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSPSPMD
PHMAEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEA
GSGAASSSGEDKENDGFVFKMPWKPTHPSSTHALAEWASRREAFAQRPSSAPDLMCLSPD
RKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILESDLKDDDAVPPGMESLISAPLVKT
LEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQ
QEAEEPKARVLRSKSLCHDEIENLLDSDHRELIGDYSKAFLLQTVDGKHQDLKYISPETM
VALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKR
VILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQ
DYRPMNHEAFKDELKTFRLKTRSWAGERSRRELCSRLQDQ
|
|
|
|---|
| BDBM50351774 |
|---|
| n/a |
|---|
| Name | BDBM50351774 |
|---|
| Synonyms: | CHEMBL1823962 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H26FNO5 |
|---|
| Mol. Mass. | 499.5295 |
|---|
| SMILES | COc1ccc(\C=C\C(=O)NC(Cc2ccc3cc(OCc4ccccc4F)ccc3c2)C(O)=O)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
