| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 6 |
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| Ligand | BDBM50351780 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_765400 (CHEMBL1828248) |
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| pH | 8±n/a |
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| IC50 | 2430±n/a nM |
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| Comments | extracted |
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| Citation |  Sun, LP; Shen, Q; Piao, HH; Ma, WP; Gao, LX; Zhang, W; Nan, FJ; Li, J; Piao, HR Synthesis and biological evaluation of (±)-3-(2-(2-fluorobenzyloxy) naphthalen-6-yl)-2-aminopropanoic acid derivatives as novel PTP1B inhibitors. Eur J Med Chem46:3630-8 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 6 |
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| Name: | Tyrosine-protein phosphatase non-receptor type 6 |
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| Synonyms: | HCP | PTN6_HUMAN | PTP1C | PTPN6 | Protein tyrosine phosphatase SHP-1 (SHP-1) | Protein-tyrosine phosphatase 1C | Protein-tyrosine phosphatase SHP-1 | Src homology phosphatase 1 (SHP-1) | Tyrosine-protein phosphatase non-receptor type 6 | Tyrosine-protein phosphatase non-receptor type 6 (SHP1) |
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| Type: | Protein |
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| Mol. Mass.: | 67570.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P29350 |
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| Residue: | 595 |
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| Sequence: | MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF
YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQA
ETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGG
LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA
KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD
YINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK
CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH
GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDC
DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNIT
YPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK
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| BDBM50351780 |
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| n/a |
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| Name | BDBM50351780 |
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| Synonyms: | CHEMBL1823762 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H23ClFNO4 |
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| Mol. Mass. | 503.949 |
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| SMILES | OC(=O)C(Cc1ccc2cc(OCc3ccccc3F)ccc2c1)NC(=O)\C=C\c1ccccc1Cl |
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| Structure | 
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