| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 2 |
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| Ligand | BDBM50351774 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_765398 (CHEMBL1828246) |
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| IC50 | 9210±n/a nM |
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| Citation |  Sun, LP; Shen, Q; Piao, HH; Ma, WP; Gao, LX; Zhang, W; Nan, FJ; Li, J; Piao, HR Synthesis and biological evaluation of (±)-3-(2-(2-fluorobenzyloxy) naphthalen-6-yl)-2-aminopropanoic acid derivatives as novel PTP1B inhibitors. Eur J Med Chem46:3630-8 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 2 |
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| Name: | Tyrosine-protein phosphatase non-receptor type 2 |
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| Synonyms: | PTN2_HUMAN | PTPN2 | PTPT | T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP) |
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| Type: | Protein |
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| Mol. Mass.: | 48481.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P17706 |
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| Residue: | 415 |
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| Sequence: | MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVK
LQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKES
VKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTW
PDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGD
DINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPA
FDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKAT
TAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
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| BDBM50351774 |
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| n/a |
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| Name | BDBM50351774 |
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| Synonyms: | CHEMBL1823962 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H26FNO5 |
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| Mol. Mass. | 499.5295 |
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| SMILES | COc1ccc(\C=C\C(=O)NC(Cc2ccc3cc(OCc4ccccc4F)ccc3c2)C(O)=O)cc1 |
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| Structure | 
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