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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Histamine H3 receptor | ||
| Ligand | BDBM50352092 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_766550 (CHEMBL1827031) | ||
| Ki | 0.32±n/a nM | ||
| Citation |  Labeeuw, O; Levoin, N; Poupardin-Olivier, O; Calmels, T; Ligneau, X; Berrebi-Bertrand, I; Robert, P; Lecomte, JM; Schwartz, JC; Capet, M Novel and highly potent histamine H3 receptor ligands. Part 2: exploring the cyclohexylamine-based series. Bioorg Med Chem Lett21:5384-8 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Histamine H3 receptor | |||
| Name: | Histamine H3 receptor | ||
| Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 48691.47 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Binding assays were using CHO cells stably expressing hH3R receptors. | ||
| Residue: | 445 | ||
| Sequence: |
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| BDBM50352092 | |||
| n/a | |||
| Name | BDBM50352092 | ||
| Synonyms: | CHEMBL1824239 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H41N3O | ||
| Mol. Mass. | 399.6125 | ||
| SMILES | CN1CCN(CC1)[C@H]1CC[C@@H](CC1)c1ccc(OCCCN2CCCCC2)cc1 |r,wU:7.7,wD:10.14,(38.82,-17.68,;37.28,-17.66,;36.49,-18.99,;34.95,-18.97,;34.2,-17.63,;34.98,-16.3,;36.52,-16.32,;32.66,-17.61,;31.88,-18.94,;30.34,-18.93,;29.58,-17.59,;30.35,-16.26,;31.9,-16.27,;28.04,-17.57,;27.26,-18.9,;25.73,-18.89,;24.96,-17.55,;23.42,-17.55,;22.65,-18.88,;21.11,-18.88,;20.34,-17.54,;18.8,-17.54,;18.04,-18.87,;16.5,-18.87,;15.72,-17.54,;16.5,-16.21,;18.04,-16.21,;25.73,-16.22,;27.27,-16.23,)| | ||
| Structure | 
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