Reaction Details | |||
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Target | Histamine H3 receptor | ||
Ligand | BDBM50352096 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_766550 (CHEMBL1827031) | ||
Ki | 0.33±n/a nM | ||
Citation | Labeeuw, O; Levoin, N; Poupardin-Olivier, O; Calmels, T; Ligneau, X; Berrebi-Bertrand, I; Robert, P; Lecomte, JM; Schwartz, JC; Capet, M Novel and highly potent histamine H3 receptor ligands. Part 2: exploring the cyclohexylamine-based series. Bioorg Med Chem Lett21:5384-8 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Histamine H3 receptor | |||
Name: | Histamine H3 receptor | ||
Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 48691.47 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Binding assays were using CHO cells stably expressing hH3R receptors. | ||
Residue: | 445 | ||
Sequence: |
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BDBM50352096 | |||
n/a | |||
Name | BDBM50352096 | ||
Synonyms: | CHEMBL1824234 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H38N2O | ||
Mol. Mass. | 370.5713 | ||
SMILES | C(COc1ccc(cc1)[C@@H]1CC[C@@H](CC1)N1CCCC1)CN1CCCCC1 |r,wU:9.9,12.16,(-5.18,-6.04,;-3.64,-6.04,;-2.87,-4.71,;-1.33,-4.71,;-.56,-6.05,;.97,-6.06,;1.75,-4.73,;.98,-3.39,;-.56,-3.38,;3.29,-4.74,;4.05,-6.09,;5.59,-6.1,;6.37,-4.77,;5.61,-3.43,;4.07,-3.41,;7.91,-4.78,;8.81,-6.04,;10.27,-5.57,;10.29,-4.03,;8.83,-3.54,;-5.95,-4.7,;-7.49,-4.7,;-8.25,-6.03,;-9.79,-6.03,;-10.57,-4.7,;-9.79,-3.37,;-8.25,-3.37,)| | ||
Structure |