| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 14 |
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| Ligand | BDBM50352565 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_767362 (CHEMBL1825474) |
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| IC50 | 0.08±n/a nM |
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| Citation |  Eastwood, P; González, J; Gómez, E; Caturla, F; Balagué, C; Orellana, A; Domínguez, M Indolin-2-one p38a inhibitors II: Lead optimisation. Bioorg Med Chem Lett21:5270-3 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 14 |
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| Name: | Mitogen-activated protein kinase 14 |
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| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 41286.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16539 |
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| Residue: | 360 |
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| Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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| BDBM50352565 |
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| n/a |
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| Name | BDBM50352565 |
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| Synonyms: | CHEMBL1825149 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H24N2O2S |
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| Mol. Mass. | 392.514 |
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| SMILES | Cc1ccc(cc1-c1ccc2c(NC(=O)C22CCSCC2)c1)C(=O)NC1CC1 |
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| Structure | 
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