| Reaction Details |
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 | Report a problem with these data |
| Target | 1-deoxy-D-xylulose 5-phosphate reductoisomerase |
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| Ligand | BDBM50352792 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_767067 (CHEMBL1826116) |
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| IC50 | >100000±n/a nM |
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| Citation |  Andaloussi, M; Lindh, M; Björkelid, C; Suresh, S; Wieckowska, A; Iyer, H; Karlén, A; Larhed, M Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: an attempt to improve the activity against Mycobacterium tuberculosis. Bioorg Med Chem Lett21:5403-7 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 1-deoxy-D-xylulose 5-phosphate reductoisomerase |
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| Name: | 1-deoxy-D-xylulose 5-phosphate reductoisomerase |
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| Synonyms: | DXR_MYCTU | dxr |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42846.92 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | ChEMBL_1474510 |
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| Residue: | 413 |
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| Sequence: | MTNSTDGRADGRLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQ
TGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTG
ARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGP
FRGWSAADLEHVTPEQAGAHPTWSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVV
VHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEP
LDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQ
WAVEPATVDDVLDAQRWARERAQRAVSGMASVAIASTAKPGAAGRHASTLERS
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| BDBM50352792 |
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| n/a |
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| Name | BDBM50352792 |
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| Synonyms: | CHEMBL1823389 |
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| Type | Small organic molecule |
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| Emp. Form. | C5H10NO5S |
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| Mol. Mass. | 196.202 |
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| SMILES | CC(=O)N(O)CCCS([O-])(=O)=O |
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| Structure | 
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