| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-S-isoprenylcysteine O-methyltransferase |
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| Ligand | BDBM50353183 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_768735 (CHEMBL1831608) |
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| IC50 | 34600±n/a nM |
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| Citation |  Bergman, JA; Hahne, K; Hrycyna, CA; Gibbs, RA Lipid and sulfur substituted prenylcysteine analogs as human Icmt inhibitors. Bioorg Med Chem Lett21:5616-9 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein-S-isoprenylcysteine O-methyltransferase |
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| Name: | Protein-S-isoprenylcysteine O-methyltransferase |
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| Synonyms: | ICMT | ICMT_HUMAN | Isoprenylcysteine carboxyl methyltransferase | PCCMT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 31943.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_956034 |
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| Residue: | 284 |
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| Sequence: | MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYR
PPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLS
LDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFT
AGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTV
WRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
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| BDBM50353183 |
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| n/a |
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| Name | BDBM50353183 |
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| Synonyms: | CHEMBL1829491 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H39NO3S |
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| Mol. Mass. | 433.647 |
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| SMILES | CCCCCCCCc1ccc(CC\C(C)=C\CSC[C@H](NC(C)=O)C(O)=O)cc1 |r| |
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| Structure | 
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