| Reaction Details |
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 | Report a problem with these data |
| Target | Protein kinase C zeta type |
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| Ligand | BDBM50353651 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_769902 (CHEMBL1831995) |
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| IC50 | 13000±n/a nM |
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| Citation |  Fröhner, W; Lopez-Garcia, LA; Neimanis, S; Weber, N; Navratil, J; Maurer, F; Stroba, A; Zhang, H; Biondi, RM; Engel, M 4-benzimidazolyl-3-phenylbutanoic acids as novel PIF-pocket-targeting allosteric inhibitors of protein kinase PKC¿. J Med Chem54:6714-23 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein kinase C zeta type |
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| Name: | Protein kinase C zeta type |
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| Synonyms: | KPCZ_HUMAN | PKC2 | PRKCZ | Protein Kinase C, zeta | Protein kinase C (PKC) | Protein kinase C iota type/zeta type | Protein kinase C zeta | Protein kinase C zeta (PKCζ) | Protein kinase C zeta type | Protein kinase C zeta type (PKC zeta) | Protein kinase C zeta type (PKCzeta) | nPKC-zeta |
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| Type: | Enzyme |
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| Mol. Mass.: | 67649.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 592 |
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| Sequence: | MPSRTGPKMEGSGGRVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKW
VDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGAR
RWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTC
RKHMDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDG
IKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTE
KHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEI
CIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAP
EILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRF
LSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQIT
DDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV
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| BDBM50353651 |
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| n/a |
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| Name | BDBM50353651 |
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| Synonyms: | CHEMBL1829841 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23IN2O2 |
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| Mol. Mass. | 462.324 |
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| SMILES | CC(C)(C)c1ccc(cc1)C(CC(O)=O)Cc1nc2ccc(I)cc2[nH]1 |
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| Structure | 
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