| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein kinase C zeta type |
|---|
| Ligand | BDBM50353653 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_769969 (CHEMBL1832243) |
|---|
| IC50 | 25000±n/a nM |
|---|
| Citation |  Fröhner, W; Lopez-Garcia, LA; Neimanis, S; Weber, N; Navratil, J; Maurer, F; Stroba, A; Zhang, H; Biondi, RM; Engel, M 4-benzimidazolyl-3-phenylbutanoic acids as novel PIF-pocket-targeting allosteric inhibitors of protein kinase PKC¿. J Med Chem54:6714-23 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein kinase C zeta type |
|---|
| Name: | Protein kinase C zeta type |
|---|
| Synonyms: | KPCZ_HUMAN | PKC2 | PRKCZ | Protein Kinase C, zeta | Protein kinase C (PKC) | Protein kinase C iota type/zeta type | Protein kinase C zeta | Protein kinase C zeta (PKCζ) | Protein kinase C zeta type | Protein kinase C zeta type (PKC zeta) | Protein kinase C zeta type (PKCzeta) | nPKC-zeta |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 67649.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 592 |
|---|
| Sequence: | MPSRTGPKMEGSGGRVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKW
VDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGAR
RWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTC
RKHMDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDG
IKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTE
KHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEI
CIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAP
EILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRF
LSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQIT
DDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV
|
|
|
|---|
| BDBM50353653 |
|---|
| n/a |
|---|
| Name | BDBM50353653 |
|---|
| Synonyms: | CHEMBL1829843 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H19ClN2O2 |
|---|
| Mol. Mass. | 390.862 |
|---|
| SMILES | OC(=O)CC(Cc1nc2ccc(cc2[nH]1)-c1ccccc1)c1ccc(Cl)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
