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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sodium-dependent noradrenaline transporter | ||
| Ligand | BDBM50354567 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_771726 (CHEMBL1838344) | ||
| Ki | 6.8±n/a nM | ||
| Citation |  Osborne, R; Clarke, N; Glossop, P; Kenyon, A; Liu, H; Patel, S; Summerhill, S; Jones, LH Efficient conversion of a nonselective norepinephrin reuptake inhibitor into a dual muscarinic antagonist-ß2-agonist for the treatment of chronic obstructive pulmonary disease. J Med Chem54:6998-7002 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sodium-dependent noradrenaline transporter | |||
| Name: | Sodium-dependent noradrenaline transporter | ||
| Synonyms: | Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2 | ||
| Type: | Multi-pass membrane protein | ||
| Mol. Mass.: | 69337.72 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23975 | ||
| Residue: | 617 | ||
| Sequence: |
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| BDBM50354567 | |||
| n/a | |||
| Name | BDBM50354567 | ||
| Synonyms: | CHEMBL1836644 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H17F2N3O | ||
| Mol. Mass. | 329.3439 | ||
| SMILES | Fc1cccc(F)c1-n1nc(OC2CCNCC2)c2ccccc12 |(8.15,4.15,;9.69,4.17,;10.44,5.51,;11.99,5.53,;12.77,4.2,;12.01,2.86,;12.79,1.54,;10.47,2.86,;9.71,1.52,;10.62,.27,;9.72,-.98,;10.51,-2.3,;12.04,-2.28,;12.82,-3.6,;14.36,-3.59,;15.11,-2.25,;14.33,-.92,;12.78,-.94,;8.25,-.5,;6.92,-1.28,;5.58,-.51,;5.59,1.03,;6.91,1.8,;8.25,1.04,)| | ||
| Structure | 
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