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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sodium-dependent noradrenaline transporter | ||
| Ligand | BDBM50354569 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_771726 (CHEMBL1838344) | ||
| Ki | 2900±n/a nM | ||
| Citation |  Osborne, R; Clarke, N; Glossop, P; Kenyon, A; Liu, H; Patel, S; Summerhill, S; Jones, LH Efficient conversion of a nonselective norepinephrin reuptake inhibitor into a dual muscarinic antagonist-ß2-agonist for the treatment of chronic obstructive pulmonary disease. J Med Chem54:6998-7002 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sodium-dependent noradrenaline transporter | |||
| Name: | Sodium-dependent noradrenaline transporter | ||
| Synonyms: | Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2 | ||
| Type: | Multi-pass membrane protein | ||
| Mol. Mass.: | 69337.72 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23975 | ||
| Residue: | 617 | ||
| Sequence: |
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| BDBM50354569 | |||
| n/a | |||
| Name | BDBM50354569 | ||
| Synonyms: | CHEMBL1836646 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H22FN3O2 | ||
| Mol. Mass. | 331.3846 | ||
| SMILES | Oc1cccc(F)c1-n1nc(OC2CCNCC2)c2CCCCc12 |(36.87,1.24,;36.09,2.57,;36.85,3.91,;36.07,5.24,;34.52,5.22,;33.77,3.88,;32.23,3.86,;34.56,2.56,;33.8,1.22,;34.71,-.02,;33.8,-1.27,;34.59,-2.59,;36.13,-2.57,;36.91,-3.9,;38.44,-3.88,;39.2,-2.54,;38.41,-1.22,;36.87,-1.23,;32.33,-.8,;31,-1.58,;29.67,-.81,;29.67,.74,;31,1.51,;32.33,.75,)| | ||
| Structure | 
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