Reaction Details |
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Target | Proton-coupled folate transporter |
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Ligand | BDBM50354833 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_771182 (CHEMBL1837099) |
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pH | 5.5±n/a |
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Ki | 130±n/a nM |
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Comments | extracted |
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Citation | Wang, L; Desmoulin, SK; Cherian, C; Polin, L; White, K; Kushner, J; Fulterer, A; Chang, MH; Mitchell-Ryan, S; Stout, M; Romero, MF; Hou, Z; Matherly, LH; Gangjee, A Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits b-glycinamide ribonucleotide formyltransferase. J Med Chem54:7150-64 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Proton-coupled folate transporter |
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Name: | Proton-coupled folate transporter |
Synonyms: | G21 | HCP1 | Heme carrier protein 1 | PCFT | PCFT/HCP1 | PCFT_HUMAN | SLC46A1 | Solute carrier family 46 member 1 |
Type: | PROTEIN |
Mol. Mass.: | 49782.13 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1469597 |
Residue: | 459 |
Sequence: | MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGT
RQRGGCSNRSADPTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLA
SLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTFR
MALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKST
RLFTFRHHRSIVQLYVAPAPEKSRKHLALYSLAIFVVITVHFGAQDILTLYELSTPLCWD
SKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFT
GYGLLFLSLVITPVIRAKLSKLVRETEQGALFSAVACVNSLAMLTASGIFNSLYPATLNF
MKGFPFLLGAGLLLIPAVLIGMLEKADPHLEFQQFPQSP
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BDBM50354833 |
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n/a |
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Name | BDBM50354833 |
Synonyms: | AGF94 | CHEMBL1834488 |
Type | Small organic molecule |
Emp. Form. | C19H21N5O6S |
Mol. Mass. | 447.465 |
SMILES | Nc1nc2[nH]c(CCCc3ccc(s3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cc2c(=O)[nH]1 |r| |
Structure |
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