| Reaction Details |
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 | Report a problem with these data |
| Target | B1 bradykinin receptor |
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| Ligand | BDBM50244617 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_772771 (CHEMBL1837510) |
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| IC50 | 11.2±n/a nM |
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| Citation |  Biswas, K; Peterkin, TA; Bryan, MC; Arik, L; Lehto, SG; Sun, H; Hsieh, FY; Xu, C; Fremeau, RT; Allen, JR Discovery of potent, orally bioavailable phthalazinone bradykinin B1 receptor antagonists. J Med Chem54:7232-46 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| B1 bradykinin receptor |
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| Name: | B1 bradykinin receptor |
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| Synonyms: | BDKRB1 | BKRB1_RABIT | Bradykinin B1 receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 39519.62 |
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| Organism: | Oryctolagus cuniculus |
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| Description: | ChEMBL_796432 |
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| Residue: | 352 |
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| Sequence: | MASQGPLELQPSNQSQLAPPNATSCSGAPDAWDLLHRLLPTFIIAIFTLGLLGNSFVLSV
FLLARRRLSVAEIYLANLAASDLVFVLGLPFWAENVRNQFDWPFGAALCRIVNGVIKANL
FISIFLVVAISQDRYSVLVHPMASRRGRRRRQAQATCALIWLAGGLLSTPTFVLRSVRAV
PELNVSACILLLPHEAWHWLRMVELNLLGFLLPLAAILFFNCHILASLRRRGERVPSRCG
GPRDSKSTALILTLVASFLVCWAPYHFFAFLECLWQVHAIGGCFWEEFTDLGLQLSNFSA
FVNSCLNPVIYVFVGRLFRTKVWELCQQCSPRSLAPVSSSRRKEMLWGFWRN
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| BDBM50244617 |
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| n/a |
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| Name | BDBM50244617 |
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| Synonyms: | (2R,3S)-2,3-dihydroxy-N-((R)-6-(piperidin-1-ylmethyl)-1,2,3,4-tetrahydronaphthalen-1-yl)-4-(3-(trifluoromethyl)phenylsulfonyl)butanamide | CHEMBL455642 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H33F3N2O5S |
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| Mol. Mass. | 554.622 |
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| SMILES | O[C@H](CS(=O)(=O)c1cccc(c1)C(F)(F)F)[C@@H](O)C(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc12 |r| |
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| Structure | 
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