Reaction Details |
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Target | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase |
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Ligand | BDBM50283498 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_772123 (CHEMBL1838042) |
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IC50 | 12000±n/a nM |
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Citation | Tang, M; Odejinmi, SI; Allette, YM; Vankayalapati, H; Lai, K Identification of novel small molecule inhibitors of 4-diphosphocytidyl-2-C-methyl-D-erythritol (CDP-ME) kinase of Gram-negative bacteria. Bioorg Med Chem19:5886-95 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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4-diphosphocytidyl-2-C-methyl-D-erythritol kinase |
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Name: | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase |
Synonyms: | 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase | CMK | ISPE_YERPE | ipk | ispE |
Type: | PROTEIN |
Mol. Mass.: | 32675.02 |
Organism: | Yersinia pestis |
Description: | ChEMBL_772123 |
Residue: | 299 |
Sequence: | MTTANQPICPSPAKWPSPAKLNLFLYITGQRADGYHQLQTLFQFLDYGDQLTIEPRDDNQ
IRLLTPIAGVENEQNLIVRAAKMLQKHPGNTPVPRGADISIDKCLPMGGGLGGGSSNAAT
VLVALNLLWQCGLTDEQLADLGLTLGADVPVFVRGHAAFAEGIGEKLQPAEPVEKWYLVI
HPGVNIPTPIIFSDPELKRNTPIRPLAALLSTPYANDCEPIARKRFREVEQALSWLLEYA
PSRLTGTGACVFAEFDTESSARQVLSIAPEWLHGFVARGVNVSPLHRVRSGKIESSERR
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BDBM50283498 |
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n/a |
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Name | BDBM50283498 |
Synonyms: | 4-[1-Furan-2-yl-meth-(Z)-ylidene]-3-phenyl-4H-isoxazol-5-one | CHEMBL80658 | cid_1834885 |
Type | Small organic molecule |
Emp. Form. | C14H9NO3 |
Mol. Mass. | 239.2262 |
SMILES | O=C1ON=C(\C1=C\c1ccco1)c1ccccc1 |c:3| |
Structure |
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