| Reaction Details |
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 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
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| Ligand | BDBM50355118 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_772292 (CHEMBL1838614) |
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| Ki | >10000±n/a nM |
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| Citation |  Liu, J; Yu, LF; Eaton, JB; Caldarone, B; Cavino, K; Ruiz, C; Terry, M; Fedolak, A; Wang, D; Ghavami, A; Lowe, DA; Brunner, D; Lukas, RJ; Kozikowski, AP Discovery of isoxazole analogues of sazetidine-A as selectivea4ß2-nicotinic acetylcholine receptor partial agonists for the treatment of depression. J Med Chem54:7280-8 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kappa-type opioid receptor |
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| Name: | Kappa-type opioid receptor |
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| Synonyms: | K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42648.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41145 |
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| Residue: | 380 |
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| Sequence: | MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRV
RNTVQDPAYLRDIDGMNKPV
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| BDBM50355118 |
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| n/a |
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| Name | BDBM50355118 |
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| Synonyms: | CHEMBL1835609 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H19N3O3 |
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| Mol. Mass. | 289.3297 |
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| SMILES | OCCCc1cc(on1)-c1cncc(OC[C@@H]2CCN2)c1 |r| |
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| Structure | 
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