| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate receptor 2 |
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| Ligand | BDBM50355329 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_773020 (CHEMBL1837939) |
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| Ki | 3150±n/a nM |
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| Citation |  Szymanska, E; Frydenvang, K; Contreras-Sanz, A; Pickering, DS; Frola, E; Serafimoska, Z; Nielsen, B; Kastrup, JS; Johansen, TN A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure: synthesis, resolution, pharmacology, and crystal structure. J Med Chem54:7289-98 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate receptor 2 |
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| Name: | Glutamate receptor 2 |
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| Synonyms: | AMPA-selective glutamate receptor 2 | GLUR2 | GRIA2 | GRIA2_HUMAN | GluR-2 | GluR-B | GluR-K2 | Glutamate AMPA 2 | Glutamate receptor 2 | Glutamate receptor AMPA 1/2 | Glutamate receptor AMPA 2/3 | Glutamate receptor ionotropic AMPA | Glutamate receptor ionotropic, AMPA 2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 98825.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Glutamate AMPA 2 GRIA2 HUMAN::P42262 |
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| Residue: | 883 |
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| Sequence: | MQKIMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTP
HIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDG
THPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINV
GNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANL
GFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALT
YDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNI
KFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTT
ILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKI
WNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLD
PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWF
SLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDL
SKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGK
YAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLL
DKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSR
AEAKRMKVAKNAQNINPSSSQNSQNFATYKEGYNVYGIESVKI
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| BDBM50355329 |
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| n/a |
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| Name | BDBM50355329 |
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| Synonyms: | CHEMBL1835336 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H13ClN2O6 |
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| Mol. Mass. | 316.694 |
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| SMILES | NC(Cc1cc(Cl)c(cc1CCC(O)=O)[N+]([O-])=O)C(O)=O |
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| Structure | 
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